Thermo Fisher Scientific ARRB2 Monoclonal Antibody (4D2)
Beta-arrestin-2(ARRB2)를 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체. Western blot, ICC/IF, ELISA에 사용 가능. 인간 및 랫트 반응성. PBS 용액 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4D2 |
| Immunogen | ARRB2 (AAH07427, 300–409 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
NLASSTIVKE GANKEVLGIL VSYRVKVKLV VSRGGDVSVE LPFVLMHPKP HDHIPLPRPQ SAAPETDVPV DTNLIEFDTN YATDDDIVFE DFARLRLKGM KDDDYDDQLC
Target Information
Beta-arrestin-2 (ARRB2) is an adaptor protein belonging to the arrestin family, containing N- and C-arrestin domains. It regulates heterotrimeric G protein-coupled receptor (GPCR) desensitization and modulates beta2-adrenergic receptor (β2AR) function by enhancing β2AR-mediated nuclear translocation of ERK. ARRB2 binds phosphorylated β2ARs, impairing their ability to activate G(S) proteins. Together with AIP4, ARRB2 mediates CXCR4 endosomal sorting into degradative pathways and may participate in hormone-specific desensitization of TSH receptors. It also functions as a Ca²⁺-binding protein in retinal outer segments, interacting with P-rhodopsin and contributing to synaptic transmission in photoreceptor cells. ARRB2 is widely expressed, particularly in neuronal tissues and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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