Thermo Fisher Scientific CUEDC2 Monoclonal Antibody (OTI2H6), TrueMAB
인간 CUEDC2 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot에 최적화됨. 고순도 액상 형태로 제공되며, 1 mg/mL 농도. 유비퀴틴 경로 관련 단백질 연구에 적합. -20°C 보관, 반복 동결/해동 방지 필요.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H6 |
| Immunogen | Full length human recombinant protein of human CUEDC2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation.
CUE domains are present in eukaryotic proteins involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found.
CUEDC2 (CUE domain-containing protein 2) was discovered through yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation via the ubiquitin-proteasome pathway.
It also decreases PR sumoylation and interacts with IKK-alpha and IKK-beta to reduce NF-kappa-B activation by inhibiting IKK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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