Thermo Fisher Scientific Kir2.1 (KCNJ2) Polyclonal Antibody
Kir2.1(KCNJ2) 단백질을 인식하는 Thermo Fisher의 토끼 폴리클로날 항체로, IHC(P)에서 1:500~1:1,000 희석 비율로 사용 가능. 인간 단백질에 반응하며, 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KCNJ2. Recombinant protein control fragment (Product # RP-90945) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642935 |
Product Specific Information
- Immunogen sequence:
YEVPNTPLCS ARDLAEKKYI LSNANSFCYE NEVALTSKEE DDSENGVPES - Highest antigen sequence identity:
Mouse – 96%, Rat – 98%
Target Information
The KIR2 subunit family includes 2.1, 2.2, 2.3, and 2.4. Unlike G protein-coupled KIR3 subunits, KIR2.1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity.
KIR2.1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels.
In the placenta, KIR2.1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2.1 colocalizes with KIR5.1 in the proximal tubule.
KIR2.1, 2.2, and 2.3 associate with the membrane-associated guanylate kinase synapse-associated protein 97 (SAP97) in the cerebellum and heart. Phosphorylation of KIR2.2 by protein kinase A inhibits the association with SAP97.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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