Thermo Fisher Scientific Phospho-RCC1 (Ser11) Polyclonal Antibody
RCC1 단백질의 Ser11 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot에 최적화되어 있으며 인간, 생쥐, 랫트 시료에 반응. 고순도 정제 및 안정한 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RCC1 (Accession P18754), corresponding to amino acid residues around phosphorylated Ser11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817602 |
Product Specific Information
Antibody detects endogenous levels of RCC1 only when phosphorylated at Ser11.
Target Information
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP.
Involved in the regulation of onset of chromosome condensation in the S phase.
Binds both to the nucleosomes and double-stranded DNA.
RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.
Plays a key role in nucleo-cytoplasmic transport, mitosis, and nuclear-envelope assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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