Thermo Fisher Scientific HIP1R Monoclonal Antibody (3E10)
HIP1R 단백질을 인식하는 마우스 단클론 항체로, Western blot과 ELISA에 적합합니다. 인간 시료에 반응하며 비결합형 액상 형태로 제공됩니다. 헌팅틴 단백질 상호작용 연구 및 암 전이 관련 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E10 |
| Immunogen | HIP1R (NP_003950, 969–1066 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SGLSLIKLKK QEMETQVRVL ELEKTLEAER MRLGELRKQH YVLAGASGSP GEEVAIRPST APRSVTTKKP PLAQKPSVAP RQDHQLDKKD GIYPAQLV
Target Information
Huntingtin disease, a neurodegenerative disorder, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntington’s disease. It also plays a role in the recruitment of clathrin coats to lipid membranes and may contribute to tumorigenesis by promoting the survival of precancerous and cancerous cells. HIP-1 expression is significantly associated with prostate and colon cancer metastasis, suggesting its potential as a prognostic factor for these cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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