Thermo Fisher Scientific CCDC8 Polyclonal Antibody
CCDC8 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P)에서 사용 가능하며, 인체 및 마우스 반응성. 고순도 친화 크로마토그래피 정제, PBS/glycerol 저장, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CCDC8 (Accession Q9H0W5), corresponding to amino acid residues F44–V94 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853089 |
Product Specific Information
Antibody detects endogenous levels of total CCDC8.
Target Information
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB, and TFEC.
The TFE3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer.
TFEC forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.
TFE3 interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing roles in cell growth, proliferation, and osteoclast/macrophage differentiation.
TFE3 also activates hepatic IRS-2 gene, induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1), participates in insulin signaling, and may serve as a therapeutic target for diabetes.
This gene is involved in chromosomal translocations resulting in fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas (e.g., PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO(p54nrb)-TFE3, ASPL-TFE3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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