Thermo Fisher Scientific CCDC8 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total CCDC8.

Target Information

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB, and TFEC.
The TFE3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer.
TFEC forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.
TFE3 interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing roles in cell growth, proliferation, and osteoclast/macrophage differentiation.
TFE3 also activates hepatic IRS-2 gene, induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1), participates in insulin signaling, and may serve as a therapeutic target for diabetes.
This gene is involved in chromosomal translocations resulting in fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas (e.g., PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO(p54nrb)-TFE3, ASPL-TFE3).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.