Thermo Fisher Scientific VGCNL1 Polyclonal Antibody
Thermo Fisher Scientific의 VGCNL1 Polyclonal Antibody는 마우스 단백질에 반응하는 토끼 유래 항체입니다. WB 및 IHC 실험에 적합하며, 내부 영역 합성 펩타이드로 면역화되었습니다. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (IHC) | 1:200–1:2,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of mouse VGCNL1 (Voltage gated channel like protein 1) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: VGCNL1.
Target Information
Nalcn is a voltage-independent, cation-nonselective channel permeable to sodium, potassium, and calcium ions. It regulates the resting membrane potential and neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P stimulate action potentials by activating NALCN via a SRC family kinase-dependent pathway. Nalcn activity is modulated by GPCRs, essential for normal respiratory rhythm, neonatal survival, and systemic osmoregulation through serum sodium control. It contributes to substance P-induced depolarization and intestinal pacemaker regulation, and plays a critical role in spontaneous firing and excitability modulation of substantia nigra pars reticulata (SNr) neurons.
Diseases associated with NALCN include congenital contractures of the limbs and face, hypotonia, developmental delay, and infantile psychomotor retardation with characteristic facies.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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