Thermo Fisher Scientific TOB1 Polyclonal Antibody, MaxPab

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKKKY EGHWYPEKPY KGSGFRCIHI GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS YQIGEKGPVK VLYVDDNNEN GCELDKEIKN SFNPEAQVFM PISDPASSVS SSPSPPFGHS AAVSPTFMPR STQPLTFTTA TFAATKFGST KMKNSGRSNK VARTSPINLG LNVNDLLKQK AISSSMHSLY GLGLGSQQQP QQQQQPAQPP PPPPPPQQQQ QQKTSALSPN AKEFIFPNMQ GQGSSTNGMF PGDSPLNLSP LQYSNAFDVF AAYGGLNEKS FVDGLNFSLN NMQYSNQQFQ PVMAN

Target Information

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein suppresses cell growth in tissue culture.
The protein undergoes phosphorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase.
Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interfere with growth suppression.
This protein inhibits T cell proliferation and transcription of cytokines and cyclins.
The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity, thereby inhibiting interleukin 2 transcription in T cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.