Thermo Fisher Scientific Mesothelin Polyclonal Antibody
Mesothelin 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체입니다. Western blot에 적합하며 인간 시료 반응성이 높습니다. 고순도 액상 형태로 제공되며 안정적인 TBS buffer에 보존됩니다. 암 관련 단백질 연구용으로 적합합니다.
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Thermo Fisher Scientific Mesothelin Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (CPSGKKAREIDES) corresponding to the internal amino acids of MSLN (aa 302–315) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10986839 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by mesothelial cells. It is expressed at low levels in normal pleural, pericardial, and peritoneal mesothelial cells but is highly expressed in mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas.
Proteolytic cleavage of Mesothelin produces a soluble fragment known as megakaryocyte potentiating factor (MPF), which may regulate megakaryocyte proliferation and platelet production. Elevated expression of Mesothelin and MPF in various cancers suggests their roles in tumorigenesis, promoting cell proliferation, migration, and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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