Thermo Fisher Scientific Human MATN3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 13 amino acids near the carboxy terminus of human MATN3.
PEP-0840 can be used as a blocking peptide with polyclonal antibody PA5-20726.

Target Information

Matrilins (MATNs) are a family of non-collagenous extracellular matrix (ECM) proteins consisting of four known members that play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs).
MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis.
MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain, whereas MATN1 is composed of two vWFA domains separated by one EGF-like domain.
MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process.
Mutations of this gene have been associated with various inherited chondrodysplasias.
Recent studies show that aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.