Thermo Fisher Scientific DDB2 Polyclonal Antibody
DDB2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. 합성 펩타이드 면역원 사용, Affinity chromatography로 정제. PBS/glycerol buffer에 저장되며 -20°C 보관.
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- PA5102498
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DDB2 (Accession Q92466), corresponding to amino acid residues T338–D388 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851900 |
Product Specific Information
Antibody detects endogenous levels of total DDB2.
Target Information
Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer participates in DNA repair following ultraviolet-induced damage. DDB, also known as UV-DDB, XPE-BF, and XAP-1, binds to damaged cyclobutane pyrimidine dimers (CPDs).
Mutations in the DDB2 gene are associated with xeroderma pigmentosum group E (XPE), an autosomal recessive disease characterized by defective nucleotide excision repair, hypersensitivity to sunlight, and increased skin cancer risk. The hepatitis B virus (HBV) X protein interacts with DDB1, potentially mediating HBx transactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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