Thermo Fisher Scientific Aconitase 1 Polyclonal Antibody
Thermo Fisher Scientific의 Aconitase 1 Polyclonal Antibody는 Human, Mouse, Rat에 반응하는 Rabbit IgG 항체로, 세포 내 철 항상성 연구에 적합합니다. IHC 및 ICC/IF에 사용 가능하며, 고순도(>95%)로 SDS-PAGE 검증되었습니다. 항원 친화 크로마토그래피로 정제된 액상 형태로, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
- 카탈로그번호
- PA586325
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–150 of Human IRP-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803108 |
Product Specific Information
- Purity: >95% by SDS-PAGE
Target Information
Aconitase 1 (ACO1), also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein that binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis.
IREs are stem-loop structures found in the 5′ UTR of ferritin mRNA and the 3′ UTR of transferrin receptor mRNA. Iron-induced binding to the IRE results in repression of ferritin translation and inhibition of transferrin receptor mRNA degradation.
Thus, IREB1 functions as a key regulator in iron metabolism and exhibits aconitase enzymatic activity, classifying it within the aconitase family of enzymes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-86325_Aconitase_1_P21399-1_Rabbit_PDP.jpeg, PA5-86325_Aconitase_1_P21399-1_Rabbit.svg)
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