Thermo Fisher Scientific SRP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

The import of proteins into the nucleus involves at least two steps:

1. Energy-independent docking of the protein to the nuclear envelope.
2. Energy-dependent translocation through the nuclear pore complex.

Imported proteins require a nuclear localization sequence (NLS), typically consisting of short regions of basic amino acids or two such regions spaced approximately 10 amino acids apart. Proteins involved in the first step of nuclear import include Xenopus importin and its yeast homolog SRP1, which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins, as well as playing a role in VJ recombination.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.