Thermo Fisher Scientific JIP3 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human JIP3 protein. Validated for IHC (paraffin) with 1:200–1:500 dilution. Antigen affinity purified and supplied in PBS with 40% glycerol. Suitable for research use in JNK signaling studies.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human JIP3 (Product # RP-104067) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term; for long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642849 |
Product Specific Information
Immunogen sequence:
AGVNLSGWRP NEDDAGNGVK PAPGRDPLTC DREGDGEPKS AHTSPEKKKA KELPEMDATS SRVWILTSTL TTSKVVIIDA NQPGTVVDQF
Antigen sequence identity:
- Mouse: 86%
- Rat: 89%
Target Information
c-Jun NH2-terminal kinases (JNKs) are members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to UV light and phosphorylates c-Jun at serine sites Ser63 and Ser73, leading to transcriptional activation.
JIP-1 (JNK interacting protein-1) acts as a cytoplasmic inhibitor of JNK, retaining it in the cytoplasm and regulating JNK-mediated gene expression. JIP-1 binds JNK1 and JNK2 with high affinity and contains both JNK binding and SH3 domains.
Multiple splice variants of JIP family members, including JIP-1b, JIP-1c (IB-1), JIP-2a, JIP-2b, and JIP-3, have been identified in brain tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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