Thermo Fisher Scientific LRRC33 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human LRRC33

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643509

Product Specific Information

Immunogen sequence: PSCVDFRNMA SLRSLSLEGC GLGALPDCPF QGTSLTYLDL SSNWGVLNGS LAPLQDVAPM LQVLSLRNMG LHSSFMALDF SGFGNLRDLD LSGNCLTTFP RFGGSLALET LDLRRNSLTA LPQKAVSEQL SRGLRTIYLS QN

Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.

Target Information

LRRC33 is a key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. It associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. It is able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta and controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.