Thermo Fisher Scientific Phospho-APC1 (Ser355) Polyclonal Antibody
Phospho-APC1 (Ser355) 폴리클로날 항체로 세포주기 관련 단백질 연구에 적합. Rabbit IgG 기반으로 IHC(P)에서 1:50~1:100 희석 사용. 액상 형태이며 -20°C 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- PA539767
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human APC1 around the phosphorylation site of Ser355 (A-H-SP-P-A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556318 |
Target Information
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis.
APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence.
The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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