Thermo Fisher Scientific FOXO4 Polyclonal Antibody
FOXO4 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 사용 가능. 인간 FOXO4의 455–505 잔기 구간을 면역원으로 제작. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C 보관 및 Wet ice 배송. 연구용 전용 제품.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 455 and 505 of human forkhead box O4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia, Trithorax Homolog, Translocated To, 7). FOXO4 belongs to the O class of forkhead/winged helix family of transcription factors, along with FOXO1, FOXO3, and FOXO6.
FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. Activation of another downstream target, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues, promoting binding to 14-3-3 proteins and subsequent nuclear export of FOXO4.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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