Thermo Fisher Scientific SMAD4 Polyclonal Antibody
SMAD4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. 인간 반응성, 고순도 정제, 2 mg/mL 농도, 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide between amino acids 400–428 from the C-terminal region of human SMAD4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552640 |
Product Specific Information
This antibody is predicted to react with bovine, mouse, porcine, and rat based on sequence homology.
Target Information
Smad4 is encoded by the Smad4 gene located on chromosome 18 in humans. Also known as Smad family member 4, Sma- and Mad-related protein 4, or Mothers against decapentaplegic homolog 4.
Smad4 contains N-terminal MH1 and C-terminal MH2 domains involved in DNA binding and protein interactions.
Upon ligand binding of the TGF-beta superfamily (including TGF-beta and BMP) to its receptor, phosphorylation of Smad1, 2, 3, 5, and 8 occurs, leading to heterotrimerization with Smad4 and nuclear translocation.
Smad4 acts as a tumor suppressor by regulating genes such as Cyclin D1 (downregulation) and collagen (upregulation), inhibiting cell proliferation. Dephosphorylation controls nuclear export and Smad dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-35330_SMAD4_Q13485-1_Rabbit.svg, PA5-35330_SMAD4_Q13485-1_Rabbit_PDP.jpeg)
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