Thermo Fisher Scientific CCDC8 Polyclonal Antibody
인간 CCDC8 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific CCDC8 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 488 and 538 of human Coiled-Coil Domain Containing 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB, and TFEC.
The TFE3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer.
TFEC forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.
TFE3 interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and differentiation.
Additionally, TFE3 activates hepatic IRS-2 gene, induces HK2 and INSIG1 expression, and participates in insulin signaling, potentially serving as a therapeutic target for diabetes.
Chromosomal translocations involving this gene produce fusion products in papillary renal cell carcinomas and alveolar soft part sarcomas (e.g., PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO(p54nrb)-TFE3, ASPL-TFE3).
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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(이미지 파일: A302-990A_CCDC8_Q9H0W5-1_Rabbit.svg / A302-990A_CCDC8_Q9H0W5-1_Rabbit_PDP.jpeg)
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