Thermo Fisher Scientific CTPS Recombinant Rabbit Monoclonal Antibody (9T4J2)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

9T4J2

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CTP synthase CTPS. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CTPS,uniProtId:P17812-1,ncbiNodeId:9606,antigenRange:200-300,antigenLength:591,antigenImageFileName:MA5-55423_CTPS_P17812-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55423_CTPS_P17812-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: SVRELRGLGL SPDLVVCRCS NPLDTSVKEK ISMFCHVEPE QVICVHDVSS IYRVPLLLEE QGVVDYFLRR LDLPIERQPR KMLMKWKEMA DRYDRLLETC S

Target Information

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as dystrophins of the nucleus to maintain nuclear organization and structura integrity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.