Thermo Fisher Scientific PARP12 Polyclonal Antibody
PARP12 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합하며, 액상 형태로 1 mg/mL 농도 제공. 4°C에서 보관, DNA 손상 반응 관련 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 300 to 350 of human Poly (ADP-ribose) polymerase 12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells.
Poly(ADP-ribose) polymerases (PARPs) constitute a family of 18 proteins encoded by different genes, sharing a conserved catalytic domain. Among them, PARP-1 (113 kDa) and PARP-2 (62 kDa) are known to have catalytic activity stimulated by DNA strand breaks.
This family plays roles in cell proliferation and cell death, interacting with common partners and localizations, suggesting fine-tuned regulation of this modification process.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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