Thermo Fisher Scientific Biliverdin Reductase Polyclonal Antibody
Thermo Fisher Scientific의 Biliverdin Reductase Polyclonal Antibody는 인간 단백질을 인식하는 토끼 다클론 항체로, Western blot 및 면역세포화학(ICC/IF)에 사용됩니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보존되어 안정성이 높습니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Biliverdin Reductase (Product #RP-92683) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.40 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856265 |
Product Specific Information
Immunogen sequence:
EPERKFGVVV VGVGRAGSVR MRDLRNPHPS SAFLNLIGFV SRRELGSIDG VQQISLEDAL SSQEVEVAYI CSESSSHEDY IRQFLNAGKH VL
Target Information
Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, converting heme to iron, carbon monoxide, and biliverdin.
BLVR is unique in being dual pH/dual cofactor-dependent, requiring NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor.
There are two isoforms:
- BLVRA (biliverdin-IX alpha-reductase): Major component of human adult liver
- BLVRB (biliverdin-IX beta-reductase): Found predominantly in fetal liver
The product, bilirubin, acts as an important antioxidant but can also be neurotoxic and cause kernicterus. In addition to antioxidant activity, it inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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