Thermo Fisher Scientific CCR2 Polyclonal Antibody
CCR2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 사용 가능. 인간, 소, 고양이, 랫드에 반응. 항원 친화 크로마토그래피로 정제된 고순도 항체.
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- PA523037
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | - |
| Immunohistochemistry (IHC) | - | 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1:50 | 1 publication |
| Flow Cytometry (Flow) | 5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Cat, Human, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to an N-terminal portion (residues 20–100) of the human CCR2 protein (UniProt ID: P41597-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153363 |
Target Information
CCR2 (C-C chemokine receptor type 2) is a key regulator of monocyte and macrophage trafficking and is upregulated during inflammation. Polymorphisms in CCR2 have been associated with resistance to HIV-1 infection and delayed progression to AIDS. Its ligand, MCP-1 (Monocyte Chemoattractant Protein-1), is produced by endothelial cells, smooth muscle cells, and macrophages, mediating monocyte activation and infiltration in inflammatory disorders such as atherosclerosis, rheumatoid arthritis, and tumor infiltration.
CCR2 is expressed in multiple tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessels. Increased expression has been observed in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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