Thermo Fisher Scientific ADSL Monoclonal Antibody (OTI2D10), TrueMAB
ADSL 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, Flow Cytometry에 사용 가능. 인간, 개, 랫드 반응성. 정제된 Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D10 |
| Immunogen | Full length human recombinant protein of human ADSL produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ADSL (adenylosuccinate lyase), also known as AMPS, ASL, or ASASE, is a 484-amino-acid enzyme involved in purine biosynthesis and AMP formation from inosine monophosphate.
ADSL catalyzes two key reactions in AMP biosynthesis:
- Removal of fumarate from succinylaminoimidazole carboxamide ribotide (SAICA ribotide) to yield aminoimidazole carboxamide ribotide (AICA).
- Removal of fumarate from adenylosuccinate to form AMP.
Defects in the ADSL gene cause adenylosuccinase deficiency, an autosomal recessive disorder associated with epilepsy, growth retardation, and muscular wasting. Multiple isoforms exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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