Thermo Fisher Scientific Human PDGF-AA, Animal-Free Recombinant Protein, PeproTech

Applications

Functional Assay (Functional)

• Assay-dependent

In vitro Assay (IV)

• Refer to 11 publications

Miscellaneous PubMed (Misc)

• Refer to 1 publication

Product Specifications

Product Specific Information

Recombinant Human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (total 250 amino acids).
This product is shipped at ambient temperature. For storage, handling, and reconstitution details, refer to the lot-specific Certificate of Analysis.

Target Information

Platelet-derived growth factor (PDGF) was identified as a major mitogenic factor in serum, secreted from activated platelets during blood coagulation. PDGF exists as three dimeric isoforms (AA, AB, BB), each composed of two related peptide chains (A and B) and acting through two receptors (α and β).
PDGF isoforms are potent mitogens for connective tissue cells including fibroblasts, glial cells, smooth muscle cells, and some epithelial and endothelial cells. They also exhibit chemotactic activity for fibroblasts, smooth muscle cells, neutrophils, and mononuclear cells.
Additional activities include stimulation of collagen synthesis, modulation of thrombospondin expression, induction of contraction in vascular tissues, and regulation of immune cell cytokine secretion. PDGF plays an important role in neuronal survival and regeneration, as well as glial cell proliferation and differentiation in the CNS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.