Thermo Fisher Scientific MCM7 Polyclonal Antibody
Thermo Fisher Scientific의 MCM7 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 항체로, Western blot, IHC, ICC/IF에 적합합니다. 재조합 단백질을 면역원으로 사용하였으며, 고순도 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MCM7 (Product #RP-102268) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789283 |
Product Specific Information
Immunogen sequence:
QSPTFMPLIM CPSQECQTNR SGGRLYLQTR GSRFIKFQEM KMQEHSDQVP VGNIPRSITV LVEGENTRIA QPGDHVSVTG IFLPILRTGF RQVVQGLLSE TYLEAHRIVK MNKSEDDESG AGE
Target Information
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and recruitment of other DNA replication-related proteins. The MCM complex consisting of MCM7 with MCM2, 4, and 6 proteins possesses DNA helicase activity and may act as a DNA unwinding enzyme.
Cyclin D1-dependent kinase CDK4 is found to associate with this protein and may regulate its binding with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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