Thermo Fisher Scientific CBL Monoclonal Antibody (6D12)
CBL 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체. Western blot과 ELISA에 적합하며, 인간 시료 반응성. 액상 형태로 제공되며 보존제가 없고 -20°C에서 보관. 연구용으로만 사용 가능.
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- pk
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Applications
- Western Blot (WB): 1–5 µg/mL
- ELISA: 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D12 |
| Immunogen | CBL (NP_005179, 736–835 a.a) partial recombinant protein with GST tag. MW of GST tag alone: 26 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Tissue culture supernatant |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
NIQSQAPSIT ESSTFGEGNL AAAHANTGPE ESENEDDGYD VPKPPVPAVL ARRTLSDISN ASSSFGWLSL DGDPTTNVTE GSQVPERPPK PFPRRINSER
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, while other Cbl proteins are ubiquitously expressed.
Cbl-c, like other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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