Thermo Fisher Scientific WRNIP1 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:50–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Rat, Dog, Horse, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Naked mole rat, Chinese hamster, and Small-eared galago

Target Information

Werner’s syndrome is a rare autosomal recessive disorder characterized by accelerated aging caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN).
The WRNIP1 protein interacts with the exonuclease-containing N-terminal portion of the Werner protein and possesses a ubiquitin-binding zinc-finger domain at the N-terminus, an ATPase domain, and two leucine zipper motifs at the C-terminus.
It shows sequence similarity to replication factor C family proteins and is conserved from E. coli to humans. WRNIP1 likely accumulates at sites of DNA damage by interacting with polyubiquitinated proteins and binds DNA polymerase delta, increasing the initiation frequency of DNA polymerase delta-mediated synthesis.
Additionally, it interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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