Thermo Scientific™

Tango™ EDNRA-bla U2OS Cells

The Tango™ EDNRA-bla U2OS cells contain the human Endothelin Receptor A (EDNRA) linked to a TEV protease site and a자세히 알아보기

The Tango™ EDNRA-bla U2OS cells contain the human Endothelin Receptor A (EDNRA) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin/TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element.

The Tango™ EDNRA-bla U2OS cell line has been functionally validated for Z`-factor and EC50 concentrations of ET-1. The EDNRA cells have been tested for assay performance under variable assay conditions. These data are available in the Validation & Assay Performance Summary in the Manuals and Brochures section.

Endothelin receptor type A (ENDRA) mediates signaling of endothelin proteins that regulate several critical biological processes, including development and function of blood vessels, production of certain hormones, and stimulation of cell growth and division. Defects in EDNRA-mediated signaling have been implicated in a wide range of diseases, including cancer, hypertension, and cardiovascular disorders.

사양

등록 번호NM_001957

어세이 입력Cell-based beta-arrestin recruitment

셀 상태Dividing Cells

세포질 후미Tail from AVPR2 GPCR

검출 방법Fluorescence

유전자 기호EDNRA

개체군 상태Pool of Stable Cells

제품라인Tango™

수량2 x 106 Cells

리포터 유전자BLA (Beta-Lactamase)

배송 조건Room Temperature

타겟 입력EDNRA

세포주U2OS

System TypeTango™

Druggable TargetGPCR

Unit SizeEach