Thermo Fisher Scientific G-CSF Recombinant Rabbit Monoclonal Antibody (243)

Applications

ELISA

• Tested Dilution: 1:1,000–1:10,000
• Publications: [References not provided]

Product Specifications

Product Specific Information

Specificity: Human G-CSF/CSF3

Target Information

G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described.
The pleiotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts, and bone marrow cells. G-CSF has specific effects on the proliferation, differentiation, and activation of hematopoietic cells.
It is also expressed by various transformed cells such as carcinoma and myeloblastic leukemia cells. G-CSF is encoded by two distinct DNA sequences, resulting in a full-size, high-activity and a shorter, low-activity isoform.
Highly conserved among species, G-CSF exerts its biological functions through interaction with its receptor expressed on hematopoietic progenitors, neutrophilic granulocytes, and certain carcinoma cell lines.
Clinically, G-CSF is used in treatment of neonatal infections, acute myocardial infarction, granulocyte transfusion in neutropenia, severe infections and sepsis, chronic autoimmune neutropenia, acute myeloid leukemia, Sweet’s syndrome, and AIDS.
It also serves as a marker protein for carcinomas such as bladder cancer, and dysfunction is linked to Kostmann Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.