Thermo Fisher Scientific CD137 Polyclonal Antibody
CD137(4-1BB) 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, Flow Cytometry, ELISA에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 연구용으로만 사용되며 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:600 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CD137 (amino acids 101–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule mainly expressed on activated T cells. Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival and clonal expansion of activated and memory CD8+ T cells, while modulating myelopoiesis and dendritic cell development. Activation of CD137 induces cytokine release that regulates peripheral monocyte survival. Soluble CD137 may serve as a negative regulator of immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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