Thermo Fisher Scientific IL-32 Monoclonal Antibody (12)

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human IL-32 alpha/IL32A.

Target Information

Interleukin-32 (IL-32) was initially identified as a transcript (NK4) selectively expressed in lymphocytes and NK cells, with expression increased following activation by IL-2. It was later re-isolated from an IL-18-treated lung carcinoma cell line and renamed IL-32.
IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms.
Treatment of human monocytic and mouse macrophage cells with IL-32 induces several proinflammatory cytokines such as TNF-α, IL-8, and MIP-2. It is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFN-γ.
These findings suggest that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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