Thermo Fisher Scientific AQR Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human AQR. Recombinant protein control fragment (Product #RP-105990). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:AQR,uniProtId:O60306-1,ncbiNodeId:9606,antigenRange:239-359,antigenLength:1485,antigenImageFileName:PA5-65273_AQR_O60306-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65273_AQR_O60306-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2662155

Product Specific Information

Immunogen sequence: SEPVTMDKVHY CERFIELMID LEALLPTRRW FNTILDDSHL LVHCYLSNLV RREEDGHLFS QLLDMLKFYT GFEINDQTGN ALTENEMTTI HYDRITSLQR AAFAHFPELY DFALSNVAEV

Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.

Target Information

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3` overhang (in vitro) (PubMed:25599396). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.