Thermo Fisher Scientific Phospho-Desmin (Ser60) Polyclonal Antibody
인산화된 Desmin(Ser60)을 인식하는 토끼 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. IHC(P), ICC/IF, peptide-ELISA에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Peptide-ELISA (pep-ELISA) | 1:10,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Desmin around the phosphorylation site of Ser60 (R-T-SP-G-G) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555430 |
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, being predominantly expressed in all types of muscle cells (cardiac, skeletal, and smooth muscle). Its expression is stage- and tissue-specific, induced during terminal development such as skeletal muscle differentiation.
In skeletal and cardiac muscle cells, desmin localizes in the Z-disk region and at the intercalated disk. Expression in smooth muscle is more heterogeneous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue (e.g., rhabdomyosarcomas and leiomyosarcomas).
During myocardial dysfunction, dramatic changes in desmin distribution have been observed.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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