Thermo Fisher Scientific NCOA6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NCOA6. Recombinant protein control fragment (Product #RP-102323). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NCOA6,uniProtId:Q14686-1,ncbiNodeId:9606,antigenRange:552-682,antigenLength:2063,antigenImageFileName:PA5-52071_NCOA6_Q14686-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52071_NCOA6_Q14686-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644523

Product Specific Information

Immunogen sequence: NQNVQHAGGQ GAGPPQNQMQ VSHGPPNMMQ PSLMGIHGNM NNQQAGTSGV PQVNLSNMQG QPQQGPPSQL MGMHQQIVPS QGQMVQQQGT LNPQNPMILS RAQLMPQGQM MVNPPSQNLG PSPQRMTPPK Q

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 92%.

Target Information

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.