Thermo Fisher Scientific DLG2 Monoclonal Antibody (6D1)
Rabbit monoclonal antibody (clone 6D1) specific for human PSD93 (DLG2). Suitable for WB, IHC-P, and Flow Cytometry. Supplied as unconjugated liquid form at 1 mg/mL. Ideal for research use in neuronal protein clustering studies.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D1 |
| Immunogen | Recombinant protein within human PSD93 aa 600–870 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
PSD-93, also known as chapsyn-110, is a plasma membrane-associated protein found in synaptic junctions. It is uniquely expressed in Purkinje neuron cell bodies and dendrites. PSD-93 contains three PDZ domains (~90 amino acids each), an interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive.
PDZ-domain interactions are thought to play a role in receptor and channel clustering, contributing to neuronal plasticity. PSD-93 participates in clustering proteins such as NMDA receptors and shaker-type potassium channels at the synaptic membrane. These interactions occur via C-terminal sequence homology (T/SXV motif). Neuronal nitric oxide synthase (nNOS), which lacks this motif but has its own PDZ domain, can also associate with PSD-93 through PDZ–PDZ interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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