Thermo Fisher Scientific XTP4 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:300

Product Specifications

Target Information

During the past decade, the role of the ERBB2 (neu/HER2) oncogene as an important predictor of patient outcome and response to various therapies in breast cancer has been clearly established.
The C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer. Identification of shared tumor-specific targets is useful in developing broadly applicable therapies.

The C35 gene is located on chromosome 17q12, 505 nucleotides from the 3′ end of the ERBB2 oncogene, the antigenic target for trastuzumab (Herceptin) therapy.
The chromosomal arrangement of the genes encoding C35 and ERBB2 is tail-to-tail. The ORF 37 open reading frame encodes a 12-kDa protein of unknown function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.