Thermo Fisher Scientific NTHL1 Recombinant Rabbit Monoclonal Antibody (22H10)
인간 NTHL1 단백질을 표적으로 하는 재조합 토끼 모노클로날 항체입니다. Western blot, IHC, ICC/IF, Flow cytometry, ELISA 등 다양한 응용에 적합합니다. 높은 특이성과 재현성을 제공하며, 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific NTHL1 Recombinant Rabbit Monoclonal Antibody (22H10)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 22H10 |
| Immunogen | A synthesized peptide derived from human NTHL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092494 |
Target Information
Oxygen radicals damage chromosomal DNA, causing cell death and inducing mutations. Although much attention has focused on repairing 8-oxo-G lesions, various other DNA damages are also caused by free-radical attack. The human NTH1 repair protein acts on multiple oxidatively damaged DNA sites. As a homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. It exhibits broad substrate specificity, recognizing numerous ring saturation and fragmentation products of pyrimidines. Research indicates that NTH plays a crucial role in the removal of oxidative base lesions in mitochondrial DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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