Thermo Fisher Scientific DACH1 Polyclonal Antibody
DACH1 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트 시료에 반응합니다. Western blot 및 IHC(P) 분석에 적합하며, 고순도 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관하며 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DACH1 (Accession Q9UI36), corresponding to amino acid residues S160–L210 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2853949 |
Product Specific Information
Antibody detects endogenous levels of total DACH1.
Target Information
Transcription factor involved in regulation of organogenesis. Regulates SIX1, SIX6, and possibly SIX5. Modulates precursor cell proliferation in myoblasts through interaction with SIX1-DACH1 complex and recruitment of EYA3. Acts as corepressor of SIX6 by repressing cyclin-dependent kinase inhibitors such as p27Kip1. Inhibits TGF-beta signaling via interaction with SMAD4 and NCOR1. Binds chromatin DNA through its DACHbox-N domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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