Thermo Fisher Scientific Nag-1 Polyclonal Antibody
NAG-1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, ELISA, IP에 사용 가능하며 인간 및 마우스 시료에 반응. 친화 크로마토그래피로 정제된 액상 형태로 -20°C에서 보관.
- 카탈로그번호
- 610-401-B87x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Nag-1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| ELISA | 1:100,000–1:120,000 |
| Immunoprecipitation (IP) | 1:500–1:7,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This affinity purified antibody was prepared by repeated immunizations with a peptide corresponding to an amino acid sequence near the C-terminal of mouse NAG-1 protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This antibody reacts with endogenous NAG-1 protein from mouse and human tissues.
A BLAST analysis suggests reactivity with NAG-1 from rat based on 100% homology.
Partial reactivity is expected against swine, bovine, and dog based on 92% homology.
Cross-reactivity with NAG-1 from other sources has not been determined.
Target Information
GDF-15 belongs to the TGF-beta cytokine family, which plays an important role during prenatal development, postnatal growth, and tissue maintenance.
It is expressed predominantly in the placenta and, to a lesser extent, in various other tissues.
The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest its involvement in gestation and embryonic development.
GDF-15 generally exerts tumor-suppressive activities and is one of the predominant factors produced in response to activation of the p53 pathway.
Serum levels of GDF-15 are positively correlated with neoplastic progression in several tumor types, including colorectal, pancreatic, and prostate cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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