Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI4G10), TrueMAB
인간 TYMS 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western Blot에 적합합니다. TrueMAB 형식으로 고순도 정제되어 있으며, PBS/BSA/glycerol buffer에 보관됩니다. DNA 합성 효소 TS 연구 및 항암제 반응 연구에 활용됩니다.
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Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI4G10), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4G10 |
| Immunogen | Full length human recombinant protein of human TYMS produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for fluoropyrimidines, an important group of antineoplastic drugs used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP, which inactivates TS by forming a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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