Thermo Fisher Scientific HLA-DOB Polyclonal Antibody
Human HLA-DOB 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. 연구용으로 HLA 및 MHC 관련 면역펩티도믹스 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HLA-DOB. Recombinant protein control fragment (Product #RP-90438) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642461 |
Product Specific Information
Immunogen sequence:
KADCYFTNGT EKVQFVVRFI FNLEEYVRFD SDVGMFVALI KLGQPDAEQW NSRLDLLERS RQAVDGVCRH NYRLGAPFTV GRKVQPEVTV YPERTPLLHQ HNLLHCSVTG FYPGDIKIKW FLNGQEERAG VMSTGPIRNG D
Highest antigen sequence identity:
- Mouse: 79%
- Rat: 77%
Target Information
Peptide (antigen) binding to major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events:
- Dissociation of class II-associated invariant chain peptides (CLIP) from the antigen-binding groove in MHC II-Ig dimers
- Activity of MHC molecules HLA-DM and HLA-DO
HLA-DM and -DO accumulate in endosomal/lysosomal compartments and on B cell surfaces, regulating CLIP dissociation and subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR) by maintaining a conformation that favors peptide exchange.
RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility.
HLA and MHC antibodies are important in Immunopeptidomics, aiding in the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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