Thermo Fisher Scientific KChIP2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitution:
Reconstitute with 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on the sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
The reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and store at -20°C.
Avoid multiple freeze-thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Voltage-gated potassium (Kv) channels are essential components of potassium currents in the heart and central nervous system.
In the heart, Kv4 channels are involved in the repolarization phase of the action potential, while in the brain they prevent reverse-propagation of action potentials.
KChIPs (Kv channel interacting proteins) are calcium-binding proteins that associate with Kv4 channels and modulate their function.
There are three known KChIPs:

• KChIP1: expressed in the brain
• KChIP2: expressed in brain, heart, and lung; has three isoforms (a, b, c)
• KChIP3 (also known as calsenilin or DREAM): expressed in brain and testis

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.