Thermo Fisher Scientific MEPCE Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal 항체로 Western blot에 적합합니다. KLH 결합 합성 펩타이드(239-267 aa)를 면역원으로 사용하였으며, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 239–267 amino acids from the central region of human MEPCE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2717636 |
Target Information
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5′-end of 7SK snRNA (7SK RNA), stabilizing it (PubMed:17643375, PubMed:19906723, PubMed:30559425).
Also functions as part of the 7SK RNP complex to sequester the positive transcription elongation factor b (P-TEFb) in an inactive state, preventing RNA polymerase II phosphorylation and transcriptional elongation (PubMed:17643375).
The 7SK RNP complex promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838).
MEPCE stabilizes 7SK RNA and facilitates 7SK RNP assembly (PubMed:19906723).
Additionally, MEPCE interacts with LARP7 within the 7SK RNP complex, occluding its catalytic center (PubMed:19906723).
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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