Thermo Fisher Scientific AFAP1L2 Polyclonal Antibody
Human AFAP1L2 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용.
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Thermo Fisher Scientific AFAP1L2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human AFAP1L2 (control fragment: Product #RP-97174) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2637743 |
Product Specific Information
Immunogen sequence:
SPTLSCLDNA TEALPADSGP GPTPDEPCIK CPENLGEQQL ESLEPEDPSL RITTVKIQTE QQRISFPPSC PDAVVATPPG ASPPVKD
Antigen sequence identity:
- Mouse: 47%
- Rat: 49%
Target Information
AFAP1L2 (also known as XB130) is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and multiple phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase.
Suppression of AFAP1L2 via siRNA reduces Src activity, IL-8 production, and EGF-induced phosphorylation of Akt and GSK3β, indicating its role as an adaptor in Src signal transduction and cellular function regulation.
AFAP1L2 is highly expressed in thyroid and acts as a substrate of RET/PTC kinase, which plays a pathogenic role in papillary thyroid cancer. Down-regulation decreases Akt activity, inhibiting cell-cycle progression and cancer cell survival, suggesting AFAP1L2 as a potential therapeutic target in thyroid cancer.
At least four isoforms of AFAP1L2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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