Thermo Fisher Scientific DDB2 Recombinant Rabbit Monoclonal Antibody (ARC0644)
Thermo Fisher Scientific의 DDB2 Recombinant Rabbit Monoclonal Antibody (ARC0644)은 인간 및 생쥐 시료에서 DDB2 단백질 검출에 적합합니다. Western blot과 ELISA에 사용 가능하며, 고순도 Affinity Chromatography로 정제되었습니다. 안정적인 액상 형태로 PBS buffer에 보관됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0644 |
| Immunogen | Recombinant fusion protein containing amino acids 220–427 of human DDB2 (Q92466) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849046 |
Product Specific Information
Immunogen sequence:
DNVGNVILLN MDGKELWNLR MHKKKVTHVA LNPCCDWFLA TASVDQTVKI WDLRQVRGKA SFLYSLPHRH PVNAACFSPD GARLLTTDQK SEIRVYSASQ WDCPLGLIPH PHRHFQHLTP IKAAWHPRYN LIVVGRYPDP NFKSCTPYEL RTIDVFDGNS GKMMCQLYDP ESSGISSLNE FNPMGDTLAS AMGYHILIWS QEEARTRK
Target Information
Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, designated DDB1 and DDB2, respectively.
The DDB heterodimer participates in repairing DNA damaged by ultraviolet light. Specifically, DDB (also known as UV-DDB, XPE-BF, and XAP-1) binds to damaged cyclobutane pyrimidine dimers (CPDs).
Mutations in the DDB2 gene can cause xeroderma pigmentosum group E (XPE), an autosomal recessive disorder characterized by defective nucleotide excision DNA repair, hypersensitivity to sunlight, and increased skin cancer risk.
The hepatitis B virus X protein interacts with DDB1, potentially mediating HBx transactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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