Thermo Fisher Scientific PDCD6 Monoclonal Antibody (2B4)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ITDWQNVFRT YDRDNSGMID KNELKQALSG FGYRLSDQFH DILIRKFDRQ GRGQIAFDDF IQGCIVLQRL TDIFRRYDTD QDGWIQVSYE QYLSMVFSIV

Target Information

An increased intracellular Ca²⁺ concentration induces apoptotic cell death. Transiently elevated Ca²⁺ concentrations are required for glucocorticoid-mediated and T cell receptor-mediated pathways, leading to T cell apoptosis.
ALG-2 (apoptosis-linked gene 2) is a Ca²⁺-binding protein that participates in regulatory events occurring late in the apoptotic program, where several death signals converge. ALG-2 is expressed in normal brain and more abundantly in ischemic brain.
The ALG-2 protein contains five EF-hand-like motifs and shares homology with members of the penta EF-hand family, including Calpain small subunits sorcin and Grancalcin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.