Thermo Fisher Scientific ESR2 Monoclonal Antibody (OTI2E12), TrueMAB
인간 ESR2(Estrogen Receptor beta)를 인식하는 Mouse monoclonal antibody. Western blot에 최적화되어 있으며, 1:500–1:2000 희석 비율로 사용 가능. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. -20°C에서 보관, 반복 동결·해동 피할 것.
- 카탈로그번호
- TA801038
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- pk
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Applications
- Western Blot (WB): Tested dilution 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–260 of human ESR2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptor beta (ERβ, NR3A2) is a member of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The protein is approximately 55 kDa, with multiple isoforms ranging from 36–59 kDa. ERβ was initially cloned from human testis and is widely expressed across various tissues. It functions as a ligand-activated transcription factor that binds to estrogen response elements (EREs) in DNA, regulating gene transcription through coactivators or corepressors.
ERβ binds estrogens with an affinity similar to ERα, and certain isoforms can inhibit ERα activity in reproductive tissues. It acts as a tumor suppressor and is implicated in diseases such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain disease, and cardiovascular disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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