Thermo Fisher Scientific PDCD4 Polyclonal Antibody
PDCD4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 종(Human, Mouse, Rat)에 반응하며 WB, IHC, ICC, ELISA 등 다중 응용 가능. 고순도 Protein A 정제, 액상 형태, 안정적인 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human PDCD4 (amino acids 1–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Apoptosis, or programmed cell death, is essential for development, tissue turnover, and tumor formation. PDCD4 (Programmed Cell Death Protein 4) is upregulated during apoptosis and encodes a tumor suppressor protein lost in various carcinomas (breast, colon, lung, prostate). PDCD4 inhibits the helicase activity of eukaryotic translation initiation factor 4A and suppresses AP-1 mediated transactivation. Akt kinase regulates PDCD4 through phosphorylation, reducing its inhibitory effect on AP-1-responsive promoters. Two isoforms of PDCD4 are known.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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