Thermo Fisher Scientific HOXA11/HOXD11 Polyclonal Antibody
HOXA11/HOXD11 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunocytochemistry에 사용 가능. Human과 Mouse 시료에 반응하며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관하며 -20°C에서 안정적으로 저장 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HOXA11 (Accession P31270), corresponding to amino acid residues P137–P187 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2851071 |
Product Specific Information
Antibody detects endogenous levels of total HOXA11/D11.
Target Information
HOX11, also called homeobox11 or Tcl-3, is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain containing protein with a glycine- and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The protein binds to specific DNA sequences and localizes to the nucleus, acting as a positive transcription activator.
The HOX11 gene is highly expressed in T-ALLs due to translocations such as t(7;10)(q35;q24) or t(10;14)(q24;q11), leading to deregulation and activation of tumor-associated target genes. These translocations are associated with T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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